Fuzheng huayu capsule

Fuzheng huayu capsule has been shown to significantly improve liver function and clinical symptoms, decrease collagen synthesis, promote degradation of extracellular matrix, reverse hepatic fibrosis, and reduce mental stress in patients with chronic hepatitis B and liver cirrhosis.

FZHY Functions:

Promoting blood circulation to remove blood stasis,replenishing vital essnce to nourish liver.

Fuzheng Huayu Capsule Reduces the Incidence of Hepatocellular Carcinoma in Patients with Hepatitis B-Caused Cirrhosis

Fuzheng huayu capsule Indications:

For hepatitis B liver fibrosis (caused by blood stasis blocking collaterals,liver and kidney deficiency).

Spec.

0.5g*60capsules/unit

Dosage:

Take Orally,3 capsules per time,thrice daily,24 weeks a treatment course.

Fuzheng huayu capsule Researches:

1. Active Components Formulation Developed from Fuzheng Huayu Recipe () for Anti-Liver Fibrosis--PUBMED.GOV

Results:

Fifteen components from Fuzheng huayu capsule showed higher scores for their activity on against liver fibrosis. FZHY attenuated liver collagen deposition, improved sinusoidal capillarization in a dose-dependent manner

Conclusion:

Fuzheng huayu exerts a satisfactory effect against experimental liver fibrosis and attenuates sinusoidal capillarization, which warrant a further research and development for herbal components formulation on liver fibrosis.

2. The Active Components of Fuzheng Huayu Formula and Their Potential Mechanism of Action in Inhibiting the Hepatic Stellate Cells Viability-- NCBI

Results:

40 active ingredients in Fuzheng huayu capsule formula and their 79 potential target proteins were identified by network pharmacology approach. Further network analysis reduced the 79 potential target proteins to 31, which were considered more likely to be the target proteins of the active components in Fuzheng huayu capsule formula. In addition, further enrichment analysis of 31 target proteins indicated that the HIF-1, PI3K-Akt, FoxO, and chemokine signaling pathways may be the primary pathways regulated by Fuzheng huayu capsule formula in inhibiting the HSCs viability for the treatment of liver fibrosis. Of the 31 target proteins, peroxisome proliferator activator receptor gamma (PPARG) was selected for validation by experiments at the cellular and molecular level. The results demonstrated that schisandrin B, salvianolic acid A and kaempferol could directly bind to PPARG, decreasing the viability of HSCs (T6 cells and LX-2 cells) and exerting anti-fibrosis effects.

Conclusion:

The active ingredients of Fuzheng huayu capsule formula were successfully identified and the mechanisms by which they inhibit HSC viability determined, using network pharmacology and transcriptomics. This work is expected to benefit the clinical application of this formula.

Fuzhenghuayu capsule clinical application

Treatment of Liver Cirrhosis(Phase 4) Due to Hepatitis B Virus With Fuzheng Huayu and Entecavir for 48 weeks

take 1 Entecavir tablet per day and 3 Fuzheng Huayu capsule one time and three times a day

The NMA showed that compared with entecavir, combined TCM did not increase the risk of adverse reactions and could significantly improve the effect of chronic hepatitis B liver fibrosis. In addition, in a variety of therapeutic strategies, the combination of Fuzheng Huayu capsule and entecavir is the best therapeutic strategy.

In this NMA, we found that 8 kinds of TCM as adjuvant medicines can improve liver fibrosis in patients with chronic hepatitis B liver fibrosis. The combination of Fuzheng Huayu capsule and entecavir is the best therapeutic strategy. It not only has a significant effect in improving the state of liver fibrosis in patients but also has a good effect in the improvement of liver function in patients. FZHY capsule is a commonly used TCM formula against liver fibrosis in clinic. It has been verified in research to exert antifibrosis effect through several mechanisms such as antilipid peroxidation and endothelial injury, inhibiting hepatic stellate cell activation, promoting matrix metalloproteinase activity, and degradation of pathological deposition of collagen.In addition, there is an article using transcriptional profiling and miRNA-target network analysis to identify potential biomarkers for efficacy evaluation of FZHY formula-treated hepatitis B caused liver cirrhosis.

FZHY effectively improves the liver function, alleviates hepatic fibrosis, decreases Child-Pugh score, and relieves TCM symptoms caused by liver dysfunction, indicating that FZHY may contribute to the alleviation of liver fibrosis and cirrhosis.

PHARMACOLOGIC ACTION

Pharmacological tests show that this product can inhibit the liver fibrosis process of carbon tetrachloride and lipid-rich diet-induced in rats, inhibition of carbon tetrachloride and D-galactosamine induced serum alanine aminotransferase increased. Long-term toxicity tests show that the product of continuous gavage administration of 6 months in rats, 2.30,0.37g / Kg rats can reduce the number of reticulocytes in rats and increase the number of white blood cells.

ADVERSE REACTION

Occasionally appears discomfort in the stomach.

Notes

Not recommended for people with damp-heat tcm symptoms

Dosage:

Take Orally,3 capsules per time,thrice daily,24 weeks a treatment course.

About Packages:

Experience package including 6 bottles with 360 capsules which may last 40 days.

1 course package including 25 bottles with 1500 capsules which may last 166 days.

combined application：

Treatment of Liver Cirrhosis(Phase 4) Due to Hepatitis B Virus With Fuzheng Huayu and Entecavir for 48 weeks

take 1 Entecavir tablet per day and 3 Fuzheng Huayu capsule one time and three times a day