Xiao Ke Wan

Xiao Ke Wan, also known as "Xiao Ke Pills" or "Diabetes Pills," is a traditional Chinese herbal medicine used to treat type 2 diabetes and its associated symptoms. It helps to lower blood sugar and could improve diabetic symptoms such as thirsty and hungry or complications such as blood lipid and blood fluid parameters.

52.5g(210tablets)/vial

Xiao Ke Wan Introduction

Xiao Ke Wan, also known as "Xiao Ke Pills" or "Diabetes Pills," is a traditional Chinese herbal medicine used to support the management of diabetes and its associated symptoms. "Xiao Ke" translates to "wasting and thirsting," which are classic symptoms of diabetes in traditional Chinese medicine.

Xiaoke Wan is proved to be highly effective with small dosage and few side effect and is especially effective for incipient, mild moderate and stable cases of diabetes mellitus in which the pancreas is still partially functioning. Since its quality is stable and its effectiveness is definite, this preparation was awarded “Famous Trade Brand Product” by Guangdong Province in 1996.

Xiao Ke Wan is composed of a combination of various herbs carefully selected for their potential effects on regulating blood sugar levels, improving insulin sensitivity, and alleviating symptoms such as excessive thirst, frequent urination, and fatigue. 

According to traditional Chinese medicine principles, Xiao Ke Wan is believed to work by tonifying the spleen and kidney, nourishing yin, and clearing heat. It aims to rebalance the body's energy and restore harmony to the organs involved in glucose metabolism.

TCM Function

Nourishes kidney-yin, benefits qi, promotes generation of body fluid.

Discussion

Xiao ke wan VS glibenclamide

Study showed that Xiaoke Pill is associated with reduced risk of hypoglycemia and has similar glucose-lowing efficacy as compared with glibenclamide. At the same level of glibenclamide dose and glycemic control, the Xiaoke Pill had clearly demonstrated a reduced incidence and rate of hypoglycemia as compared with glibenclamide, suggesting that the TCM in the Xiaoke Pill had protective effects against hypoglycemia induced by glibenclamide.

Analysis of combination of Xiaokewan Decoction with metformin and insulin

10 western drugs or combinations were included: insulin, metformin tablets, Eugenol 25, Damicon + Gehuazhi, 1/20 original medicine + rice, sitagliptin, gliclazide tablets, Xiaoke Pills + metformin tablets, glibenclamide + metformin tablets, and regraine. Among them, Xiaokewan combined with metformin and insulin were the most commonly used. 

Twenty-three studies based on metformin showed that the combined use of Xiaokewan could significantly improve the treatment of diabetes. Twenty of these studies showed that Xiaoke Decoction was effective in improving total efficiency.

Studies and Researches

Xiao Ke Wan has been the subject of several studies and research papers, particularly in the field of traditional Chinese medicine. Some of the research has focused on the individual herbal components of Xiao Ke Wan, while others have examined the formula as a whole. Here are a few key findings:

① Blood sugar regulation: Several studies have investigated the potential hypoglycemic effects of Xiao Ke Wan. Research suggests that the herbal ingredients in Xiao Ke Wan may help regulate blood sugar levels by improving insulin sensitivity, enhancing glucose uptake, and reducing insulin resistance.

② Antioxidant activity: Some studies have indicated that Xiao Ke Wan exhibits antioxidant properties. Antioxidants help reduce oxidative stress, which is believed to play a role in the development and progression of diabetes-related complications.

③ Anti-inflammatory effects: Inflammation is associated with insulin resistance and the development of diabetes. Research suggests that Xiao Ke Wan may possess anti-inflammatory properties, which could potentially contribute to its therapeutic effects.

④ Renal protection: Diabetes can lead to kidney damage and dysfunction. Some studies have suggested that Xiao Ke Wan may have a protective effect on the kidneys, potentially reducing the risk of diabetic nephropathy.

Dosage

Take orally. take 5-10 pill 30 mins before meals and 2-3 times daily with warm water.Or follow medical directions.

For first period of treatment: 10 pills per time and 3 times daily is recommended. 1 month as one period of treatment.

Packages

Recommended package including 10 packs with 2100 pills which may last 70-210 days.

Xiaokewan combined with metformin and insulin were the most commonly used

Note

Xiao ke wan contains glyburide(1 pill contains 0.25mg.). Do not take with glyburide together.

Taboo

1.Do not use for people with Severe liver and kidney dysfunction.

2. Do not use for  insulin-dependent patients.

3. Do not take with glyburide together.

Advice

Additionally, it's crucial to remember that diabetes management requires a comprehensive approach, including dietary modifications, regular exercise, monitoring blood sugar levels, and, if necessary, prescribed medications. Xiao Ke Wan should not be used as a substitute for conventional medical care but rather as a potential complementary therapy under the guidance of a healthcare professional.